Genetic panel data like the one produced by 23andMe gives information about a person’s potential health factors. Leucine Rich Bio provides a comprehensive analysis of genetic panel data. At our introductory price of INR 1320 (USD 20), our Genome Health Report provides you and your physician with genetic risk factors. To submit your data please click the link above and follow the instruction listed.
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Prevention and management of Cardiovascular disease (CVD), particularly Ischemic Heart Disease and Stroke, present a difficult challenge for health care and public health. Genetic variant studies have shed a light on many CV diseases. Example, Familial defective Apolipoprotein B (APOB) is another form of Familial Hypercholesterolemia in which Low-density lipoprotein (LDL) binds defectively to the LDL receptor, which results in increased circulating Low-density lipoprotein cholesterol (LDLc) levels and premature Atherosclerosis. The molecular defect responsible for familial defective APOB is a single mutation (R3500Q) in the gene encoding APOB, the main apolipoprotein in LDL that binds to the LDL receptor1.
Transporters are proteins in cell membranes that regulate the passage of molecules, including drugs, into and out of cells. There are major differences in the type and frequency of transporter genetic variations among Caucasians, Asians, Latinos, and African-Americans. Example, It is now known that variations in a genetic locus that codes for ATP Binding Cassette (ABCG2), a membrane transporter protein that regulates the drug’s access to certain areas of the kidney, plays a major role in allopurinol response. Similarly, a transporter called organic cation transporter 1 (OCT1) is crucial to metformin’s absorption into liver cells (hepatocytes) and variations in that protein altered the drug’s effects in studies of both healthy human volunteers and diabetic patients1.