GENETIC PANEL

GENETIC PANELS

Genetic panel data like the one produced by 23andMe gives information about a person’s potential health factors. Leucine Rich Bio provides a comprehensive analysis of genetic panel data. At our introductory price of INR 1320 (USD 20), our Genome Health Report provides you and your physician with genetic risk factors. To submit your data please click the link above and follow the instruction listed.



WHY LEUCINE RICH BIO FOR YOUR DATA ANALYSIS?

  • We understand the complexities of genomic data and its implication in disease, well being and treatment. Our proprietary analysis platform (AGIS) along with manually curated database (LRB-HGVD) with 5000+ diseases and 60000+ variant annotations provide a cutting edge to our interpretation.
  • Our clinician friendly report helps in making the complex data look simple.
  • We understand the genomic healthcare ecosystem well and are very economically priced.
  • We follow HIPAA guidelines and ensure Physical, Network and Process Security measures are all in place. All our employees are trained for compliant security procedures, policies, risk response and reporting, password use and data protection. We adhere to international Privacy Standards and place utmost security in saving, sharing and accessing of medical and personal information of any individual. Read more.....

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    CARDIOVASCULAR SYSTEM

    Prevention and management of Cardiovascular disease (CVD), particularly Ischemic Heart Disease and Stroke, present a difficult challenge for health care and public health. Genetic variant studies have shed a light on many CV diseases. Example, Familial defective Apolipoprotein B (APOB) is another form of Familial Hypercholesterolemia in which Low-density lipoprotein (LDL) binds defectively to the LDL receptor, which results in increased circulating Low-density lipoprotein cholesterol (LDLc) levels and premature Atherosclerosis. The molecular defect responsible for familial defective APOB is a single mutation (R3500Q) in the gene encoding APOB, the main apolipoprotein in LDL that binds to the LDL receptor1.

    References

    1. Soria LF, Ludwig EH, Clarke HR, Vega GL, Grundy SM, McCarthy BJ. Association between a specific apolipoprotein B mutation and familial defective apolipoprotein B-100. Proc Natl Acad Sci U S A. 1989 Jan;86(2):587-91.

    Genomic variants role in

    DRUG ABSORPTION

    Transporters are proteins in cell membranes that regulate the passage of molecules, including drugs, into and out of cells. There are major differences in the type and frequency of transporter genetic variations among Caucasians, Asians, Latinos, and African-Americans. Example, It is now known that variations in a genetic locus that codes for ATP Binding Cassette (ABCG2), a membrane transporter protein that regulates the drug’s access to certain areas of the kidney, plays a major role in allopurinol response. Similarly, a transporter called organic cation transporter 1 (OCT1) is crucial to metformin’s absorption into liver cells (hepatocytes) and variations in that protein altered the drug’s effects in studies of both healthy human volunteers and diabetic patients1.

    References

    1. Stocker SL, et al. The effect of novel promoter variants in MATE1 and MATE2 on the pharmacokinetics and pharmacodynamics of metformin. Clin Pharmacol Ther. 2013 Feb;93(2):186-94.

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