Advanced Genome Interpretation Suite (AGIS) is a Clinical Data Analysis Platform for Analyzing and Interpreting Clinically Relevant Sequence information from Human Genomes. AGIS uses powerful algorithms to report precise Disease Causing Mutations. AGIS's algorithms are designed to provide information in a fast yet accurate manner. AGIS inputs Sequence Reads and outputs mutation analysis reports.
AGIS combines powerful Analysis Algorithms and Verified Genome Functional Data to give the user Actionable and Clinically significant Variants. AGIS's report would include Physician Tailored Summaries as well as Detailed Analysis.
Human Genome Variation Database (HGVD) is an in house database curated and maintained by Leucine Rich Bio™. The database provides functional information, mutation impact on disease, drug response and variant impact on protein structure and functions. HGVD is tailored to provide variant information to AGIS.
AGIS runs on the Cloud, is secure and provides storage for Variants. Some of the main functions and features of AGIS are mentioned below:
It is recognised that variant calling algorithms vary slightly in variant detection. Hence AGIS uses two variant calling algorithms to identify variants. In this way AGIS tries to maximise the potential of each individual algorithm. The primary algorithm is used is Wellcome Trust's Platypus. The secondary algorithm used is Leucine Rich Bio in-house developed algorithm to call variants. Both algorithms have been extensively tested for sensitivity and specificity of human data.
Variants called are ranked based on clinical relevance. An in-house developed Ranking Algorithm is used to rank the variants. The algorithms considers multiple factors including variant pathogenicity, variant type, allele frequency among several factors to rank the variants. At present more than 15 factors and annotation from multiple biological databases are used to rank the variants. The algorithm has been extensively tested for specificity, sensitivity and reproducibility.
Reports are generated based on ranked variants. Reports are broadly of two types:
- Summary Report:Summary Report will contain clinically relevant data which are highly significant. It is the summary of the findings from the genome and is tailored for a clinician.
- Full Report:The full report will contain all relevant and supporting information. It will contain all the variants that have been detected, its annotation, its scoring and its clinical significance. Reports have been structured as recommended by the ACMG guidelines.
As we deal with Protected Health Information (PHI) we ensure Physical, Network and Process Security measures are all in place. All our employees are trained for compliant security procedures, policies, risk response and reporting, password use and data protection.We adhere to international Privacy Standards and place utmost security in saving, sharing and accessing of medical and personal information of any individual. AGIS runs on high end compute infrastructure for maximum efficiency. Strict data privacy and security are in place to ensure all data is secure. For high end users, AGIS can be deployed on any private cloud around the world.